Kris De Baerdemacker studied composition at the Royal Conservatory of Ghent with Godfried-Willem Raes. He composed his first works for player piano, for which he devised several dozen studies. They were successfully performed at festivals in Belgium, the Netherlands, Poland, France, Lithuania, and elsewhere by the M&M ensemble of the Logos Foundation.

Later, he also began to focus on instrumental music and created several compositions for soloists and ensembles. The Nadar Ensemble, the Spectra Ensemble, the Collectief, the National Orchestra of Belgium, the Ghent University Orchestra, Artis Dulcedo, the Kalès Guitar Quartet, and many others have performed his work. Kris De Baerdemacker's music has been performed at various venues, including the Ghent International Organ Festival (2003), De Nieuwe Reeks (2006), Klarafestival Dendermonde (2006), the Ghent Week of Contemporary Music (2007, 2008), and the Transit Festival (2008).

In 2006, his first orchestral work, "Blending," was selected for the Tactus Young Composers' Forum and awarded a laureate prize.

Several recordings of his works have since been released on CD.